Pilani Campus

Aug 29, 2024 | pubs.rsc.org | Science Pilani |Pilani Campus |Shivani Kirad |Sonakshi Puri

An insight into advances and challenges in the development of potential stearoyl Co-A desaturase 1 inhibitors Stearoyl-CoA desaturase 1 (SCD1) is one of the key enzymes involved in lipid metabolism, plays a vital role in the synthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs).

Jul 11, 2024 | link.aps.org | Arpan Das |Science Pilani |Pilani Campus |Partha Bagchi

In high multiplicity proton-proton (p−p) collisions, the formation of a deconfined state of quarks and gluons akin to heavy ion collisions (HIC) has been a subject of significant interest. In proton-proton (p−p) collisions, the transverse size of the system is comparable to the longitudinal (Lorentz contracted) dimension, unlike the case in a nucleus-nucleus (A−A) collision, leading to a hitherto unexplored effect of rapid decrease of temperature of the medium on quark-antiquark bound states.

Jun 6, 2024 | pubs.rsc.org | Sakshi Priya |Science Pilani |Pilani Campus |Gautam Singhvi

Determination of 3-acetyl-11-keto-β-boswellic acid in analytical and biological samples using streamlined and robust RP-HPLC method† AKBA (3-acetyl-11-keto-β-boswellic acid) is a phytoconstituent derived from Boswellia serrata extract and utilized in the management of rheumatoid arthritis. Drug delivery approaches showed interest in delivering AKBA with advanced nanotechnology.

Dec 11, 2023 | pubs.rsc.org | Dhananjay S Nipate |Science Pilani |Pilani Campus |Neha Meena

Rh(iii)-catalyzed oxidative [4+2] annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols† Synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines has been developed through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols, respectively.

May 23, 2023 | pubs.rsc.org | Science Pilani |Pilani Campus |Vishwadeep Shelke |Ajinath Kale

Concomitant inhibition of TLR-4 and SGLT2 by phloretin and empagliflozin prevents diabetes-associated ischemic acute kidney injury† Vishwadeep Shelke, a   Ajinath Kale,a   Neha Dagar,a   Tahib Habshia  and  Anil Bhanudas Gaikwad *a   Abstract Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is involved in the pathogenesis of diabetes-associated kidney diseases.