Pooja Middha

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Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis - Nature Communications

Mar 26, 2024 | nature.com | Pooja Middha |Michael Betti |Cosmin Bejan |Douglas Johnson |Linda Kachuri |Christine Lovly | +4 more

AbstractImmune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn’s disease (CD) and ulcerative colitis (UC) predisposes to IMC.

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