Pooja Toshniwal Paharia

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent Nature Communications study explored how synaptic vesicle (SV) composition changes with age and α-synuclein (αSyn)-related disease. The researchers focused on the role of αSyn in maintaining synaptic health, with the goal of informing therapies that could restore normal function by adjusting αSyn levels. This protein, known for accumulating in Lewy bodies, is a key driver of neurodegeneration in disorders such as Parkinson’s disease (PD).

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Cell investigates how lamina-associated domains (LADs) contribute to nuclear genome organization in early-stage mouse embryos. Focusing on the zygote and two-cell stages, the researchers examined the interplay between chromatin structure, nuclear architecture, and epigenetic pathways. Their findings show how the nuclear lamina influences genome positioning and stability during early development.

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Nature reveals that recalling cold experiences can trigger significant physiological responses in the body, boosting metabolism, thermogenesis in brown adipose tissue (BAT), and the breakdown of glucose and lipids. This memory-induced thermoregulation suggests potential applications for treating metabolic conditions like diabetes and obesity.

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Science Advances introduces a new approach to three-dimensional (3D) printing that integrates cells and extracellular matrix (ECM) into biologically functional scaffolds. Image Credit: luchschenF/Shutterstock.comThese collagen-based, high-resolution, internally perfusable scaffolds, referred to as CHIPS, work in tandem with a customizable vascular and perfusion organ-on-a-chip reactor system (VAPOR).

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerIn a recent Genomics Psychiatry interview for the Innovators & Ideas series, Dr. Jeremy Poschmann of the French National Institute of Health and Medical Research (INSERM) and Nantes University discusses his data-focused approach to unraveling disease risk. By integrating multi-omics data and immune profiling, Dr. Poschmann explores how pre-existing immune conditions shape individual responses to pathogens.