Poornima Kumar

Feb 27, 2024 | biologicalpsychiatryjournal.com | Lisa D. Nickerson |David Harper |Poornima Kumar

Delay discounting (DD) is a transdiagnostic NIMH RDoC positive valence system (PVS) sub-construct that is impaired across various psychiatric disorders. Understanding relationships between RDoC measures across levels of analysis (LA) to link brain circuitry to behavior to self-report LA is critical to enhance the utility of RDoC for research on psychiatric disorders. We examine the links between multi-modal MRI patterns from data fusion and PVS DD and self-report UA to parse the DD sub-construct.

Feb 1, 2024 | nature.com | Poornima Kumar |Quentin Devignes

AbstractTrauma-related intrusive memories (TR-IMs) are hallmark symptoms of posttraumatic stress disorder (PTSD), but their neural correlates remain partly unknown. Given its role in autobiographical memory, the hippocampus may play a critical role in TR-IM neurophysiology. The anterior and posterior hippocampi are known to have partially distinct functions, including during retrieval of autobiographical memories.

Dec 27, 2023 | jamanetwork.com | Poornima Kumar |Peter S. Dayan |Thomas Wolfers

From Complexity to Precision—Charting Decision-Making Through Normative Modeling Data-driven and theory-driven branches of computational psychiatry agree on the literal importance of normative modeling but differ in their interpretations of the term.

Jun 26, 2023 | medium.com | Poornima Kumar

By Poornima Kumar Photo by Andrea Leopardi on Unsplash In April 2023, India surpassed the population of China and now holds the record of being the world's most populous country. With the rate of Indians migrating overseas increasing every year and just because of the sheer population, chances are you have met at least one Indian in your life. You either have an Indian friend or a colleague, or a neighbor. Or perhaps you encountered a few during your travels.

May 9, 2023 | nature.com | Poornima Kumar |Nikolaos P. Daskalakis |Kerry J. Ressler

AbstractThe pituitary adenylate cyclase-activating polypeptide (PACAP) system is implicated in posttraumatic stress disorder (PTSD) and related amygdala-mediated arousal and threat reactivity. PTSD is characterized by increased amygdala reactivity to threat and, more recently, aberrant intrinsic connectivity of the amygdala with large-scale resting state networks, specifically the default mode network (DMN).