Pratishtha Chatterjee

Oct 30, 2024 | onlinelibrary.wiley.com | Pratishtha Chatterjee |James D. Doecke |Nicholas Ashton |Tahmida Sharmin

1 INTRODUCTION Given a multifactorial disorder, Alzheimer's disease (AD) pathogenesis involves dysregulation in diverse biochemical processes (Dorszewska et al., 2016; Koutsodendris et al., 2022; López-Ortiz et al., 2021), including abnormal amyloid-β (Aβ) production and impaired Aβ clearance, tau hyperphosphorylation, insufficiency in brain glucose utilisation, mitochondrial dysfunction, lipid dyshomeostasis, oxidative stress, neuroinflammation and neurotransmitter dyshomeostasis (Toledo et...