Praver Gupta

3 weeks ago | nature.com | Praver Gupta |Tamal Das

Healthy tissue microenvironment sustains homeostasis, evasion of which can lead to premalignant lesions. This is seen, for example, in APC-deficient intestinal stem cells (ISCs) that form adenomas, which are precursors to colorectal cancer (CRC). APC deficiency confers ISCs with an advantage, whereby they outcompete normal ISCs in the intestine. Although it is known that loss of APC leads to unchecked activation of the WNT pathway, the underlying mechanisms remain incompletely understood.