Premal Shah

2 weeks ago | biorxiv.org | |Premal Shah

AbstractAcross taxonomical domains, synonymous codons of an amino acid are found to be used at unequal frequencies within genes. This codon usage bias (CUB) is highly variable across species. Genome-wide CUB reflects a balance between adaptive and non-adaptive microevolutionary processes within a species. Variation in microevolutionary processes results in across-species variation in CUB.

Sep 28, 2024 | biorxiv.org | |Premal Shah

AbstractAcross the major taxonomical domains, synonymous codons of an amino acid are found to be used in unequal frequencies. This codon usage bias -- both in terms of the degree of bias and the identity of codons used -- is highly variable, even among closely related species. Within a species, genome-wide codon usage bias reflects a balance between adaptive and non-adaptive microevolutionary processes.

May 30, 2024 | ecoevorxiv.org | |Premal Shah |Edward Wallace |Michael A. Gilchrist

Downloads Download Preprint Authors Abstract Synonymous codons are used unevenly despite coding for the same amino acid. Recent work has provided critical insights into the functions, mechanisms, and fitness consequences of codon usage bias and synonymous mutations. However, experiments aimed at understanding the role of synonymous mutations often involve only a small number of reporter genes.