Qian Yan

Nov 20, 2023 | onlinelibrary.wiley.com | Qian Yan |Xiaona Fang |Xiaoxia Liu |Sai Guo

1 Introduction Tumor cells are known to display properties reminiscent of fetal development, contributing to cellular diversity and tumor evolution1] The gene expression signature and key signaling pathways of fetal development are invariably harnessed by tumor cells to facilitate malignant transformation2] Hepatocellular carcinoma (HCC) is the second most prevalent cause of cancer-associated mortality worldwide, with an inferior prognosis3] Similar to many other tumors, HCCs regain the...