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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Shukang Zhang
AbstractSecondary eggshell units, though rarely observed in modern avian eggshells, are marked structures in non-avian dinosaur eggshells that offer valuable paleobiological insights. Despite their significance, the origins of secondary eggshell units remain understudied, leading to debates in paleontology, including the hypothesis of an abiogenic origin for these structures.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Luyang Gao
AbstractGlucagon-like peptide–1 (GLP-1), secreted by intestinal L cells, is essential for lowering postprandial glucose levels and regulating hepatic lipid metabolism.We investigate the effects of manipulating Piezo1 in L cells on hepatic lipid metabolism.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Jingmin Kang
AbstractCis-regulatory elements (CREs) direct precise gene expression for development and environmental response, yet their spatial organization in crops is largely unknown. We introduce transposase-accessible chromosome conformation capture (TAC-C), a method integrating ATAC-seq and Hi-C to capture fine-scale chromatin interactions in four major crops: rice, sorghum, maize, and wheat.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li
Skip to main content Main content starts here In the original version of the Research Article “Rational polyelectrolyte nanoparticles endow preosteoclast-targeted siRNA transfection for anabolic therapy of osteoporosis” by Z. Zhang et al., the photomicrograph in Fig. 5F representing the “*NP2-siNC” experimental cohort was inadvertently duplicated in the “NC” group.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Youzhi Xu
AbstractIndoles represent one of the most robust and synthetically versatile classes of heteroaromatic compounds. However, the stereoselective conversion of planar indole rings into three-dimensional indoline skeletons bearing multiple stereogenic centers remains a persistent challenge in organic synthesis. Herein, we describe an intermolecular catalytic asymmetric dearomatization of simple indoles via a palladium-catalyzed three-component cross-coupling reaction.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Zifan Wang
AbstractDavemaoite (CaSiO3 perovskite) is an essential mineral in Earth’s lower mantle, thought to be solidified directly from an early magma ocean. Despite its abundance, the impact of defects, particularly oxygen vacancies, on davemaoite’s properties under mantle conditions has not been thoroughly investigated. Here, we use machine learning molecular dynamic simulations to examine the behavior of oxygen-deficient davemaoite structures under high pressures and temperatures.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Simok Lee
AbstractVariable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft electronics in a single system through dynamic mechanical modulation. While gallium’s high modulus tuning ratio and rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, high surface tension, and unintended phase transitions during processing pose substantial challenges.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Wanting Zhu
AbstractBacterial wilt caused by Ralstonia solanacearum is a devastating plant disease. Exopolysaccharide (EPS), a major virulence factor of R. solanacearum, elicits pattern-triggered immunity (PTI) in tomato, but the means by which EPS is recognized in the plant remain poorly understood. We found that tomato non-arginine-aspartate (non-RD) receptor kinase SlLYK4 mediates the perception of R. solanacearum EPS and positively regulates resistance to bacterial wilt.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Zhaonan Chen
AbstractBasal forebrain cholinergic neurons (BFCNs) influence cognition and emotion through specific acetylcholine release in various brain regions, including the prefrontal cortices and basolateral amygdala (BLA). Acetylcholine release is controlled by distinct BFCN subtypes, modulated by excitatory and inhibitory inputs. However, the organization of the whole-brain input-output networks of these subtypes remains unclear.
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4 weeks ago | 
science.org | Qiming Liu |Yao Ma |Hui Li |Fabian Munder
AbstractPyrroloquinoline quinone (PQQ) is a soluble redox cofactor used by diverse bacteria. Many Gram-negative bacteria that encode PQQ-dependent enzymes do not produce it and instead obtain it from the environment. To achieve this, Escherichia coli uses the TonB-dependent transporter PqqU as a high-affinity PQQ importer.
