Qin Ma

Jun 25, 2024 | nature.com | Qin Ma

Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practices in applying foundation models to interrogate data and improve downstream tasks in single-cell omics.

Dec 22, 2023 | onlinelibrary.wiley.com | Tao Yuan |Ji Sun |Sichuan Chengdu |Qin Ma

1 CASE PRESENTATION A 23-year-old Chinese male presented to the emergency department with persistent diffuse abdominal pain for 2 days after overdose intake of antihypertensive drugs (including 60 nifedipine tablets, 14 olmesartan tablets, and 50 clonidine tablets). He had a medical history of nephrotic syndrome for 18 years and episode of secondary acute left cerebral infarct 2 years ago. Long-lasting illness and suffering caused him depression and even suicide attempts.

Jul 19, 2023 | pubmed.ncbi.nlm.nih.gov | Ting Hu |Qin Ma

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Mar 30, 2023 | nature.com | Qin Ma |Sergio Baranzini |Stephen L. Hauser |Roland Henry

AbstractGenome-wide association studies (GWAS) successfully identified multiple sclerosis (MS) susceptibility variants. Despite this notable progress, understanding the biological context of these associations remains challenging, due in part to the complexity of linking GWAS results to causative genes and cell types. Here, we aimed to address this gap by integrating GWAS data with single-cell and bulk chromatin accessibility data and histone modification profiles from immune and nervous systems.