Qingyun Li

1 month ago | frontiersin.org | Zhaohui Cui |Li Gao |Qingyun Li |Dayong Shen |Wei Zhang

Jan 9, 2024 | cell.com | Qingyun Li

Advanced age and the APOE4 genetic variant are the dominant risk factors for late-onset Alzheimer’s disease (AD). Millet et al. examine AD mouse models and identify a microglial population defined by expression of inflammatory signals and cell-intrinsic stress markers whose frequency increases with age and APOE4 burden. This state, associated with functional defects, is found also in human AD.

Dec 19, 2023 | journals.plos.org | Qingyun Li

The pituitary, situated at the hub of the neuroendocrine system, produces distinct hormones in response to neuronal activation in the hypothalamus, thereby modulating the secretory activities of peripheral glands, such as the generation of glucocorticoids by the adrenal cortex [1]. This constitutes the hypothalamus–pituitary–adrenal (HPA) axis, which plays a pivotal role in regulating diverse physiological functions as well as immune responses under homeostasis and stress conditions.