Qiuhui Hu

Sep 16, 2023 | pericles.pericles-prod.literatumonline.com | Huiming Ren |Qiuhui Hu |Jiajia Yang |Xiaoxuan Zhou

The tumor entrance of drug delivery systems, including therapeutic proteins and nanomedicine, plays an essential role in affecting the treatment outcome. Nanoparticle size is a critical but contradictory factor in making a trade-off among blood circulation, tumor accumulation, and penetration. Here, we designed a series of single-molecule gadolinium (Gd)-based magnetic resonance imaging (MRI) nanoprobes with well-defined sizes to precisely explore the size-dependent tumor entrance in vivo.