Qiyuan Li

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SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice - Cell Death & Differentiation

Oct 14, 2024 | nature.com | Shuai Wang |Ting He |Qiyuan Li |Weihua Li |Huiling Guo

AbstractBrown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found SOX4 is required for BAT development and thermogenic program. Depletion of SOX4 in BAT progenitors (Sox4-MKO) or brown adipocytes (Sox4-BKO) resulted in whitened BAT and hypothermia upon acute cold exposure.

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