Rakesh K. Jain

Jan 15, 2025 | nature.com | Hadi T. Nia |Rakesh K. Jain

AbstractThe physical microenvironment plays a crucial role in tumor development, progression, metastasis and treatment.

Oct 10, 2024 | nature.com | Rakesh K. Jain

AbstractBeyond their many well-established biological aberrations, solid tumours create an abnormal physical microenvironment that fuels cancer progression and confers treatment resistance. Mechanical forces impact tumours across a range of biological sizes and timescales, from rapid events at the molecular level involved in their sensing and transmission, to slower and larger-scale events, including clonal selection, epigenetic changes, cell invasion, metastasis and immune response.

Oct 5, 2024 | nature.com | Bo R. Rueda |Rakesh K. Jain

AbstractOvarian cancer (OvCa) is the most lethal of the gynecologic malignancies. Immune checkpoint inhibitors, which have revolutionized the treatment of multiple malignancies, have had limited efficacy in OvCa patients. This lack of effectiveness is partly due to the abnormal ovarian tumor microenvironment (TME), displaying a desmoplastic, highly fibrotic extracellular matrix.