Randy J. Seeley

Jul 31, 2023 | nature.com | Randy J. Seeley

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Jun 19, 2023 | nature.com | Samuel Klein |Randy J. Seeley

Many people with obesity and type 2 diabetes achieve remission of their diabetes after Roux-en-Y gastric bypass surgery, but the mechanisms of remission remain disputed. We provide our perspective on competing datasets that point towards this effect being due either entirely to the loss of weight or to weight loss-independent effects. Type 2 diabetes (T2D) in people with obesity is caused by multi-organ insulin resistance, in conjunction with impaired pancreatic β-cell function.