Raphaella W.L. So

Jan 7, 2025 | cell.com | Morgan G. Stykel |Carla L. Coackley |Ping Lu |Raphaella W.L. So |Erica Stuart |Jeffery Joseph | +12 more

Keywordsalpha-synucleinG6PDParkinson's diseaseoxidative stressdopaminehiPSCResearch topic(s)CP: NeuroscienceIntroductionThe decline of voluntary motor function in Parkinson’s disease (PD) is caused, in part, by loss of A9 dopaminergic neurons in the substantia nigra pars compacta.

Mar 30, 2024 | biorxiv.org | Erica Stuart |Adriano Aguzzi |Raphaella W.L. So |Aeen Ebrahim Amini

AbstractThe cellular prion protein, PrPC, has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson's disease. To test this hypothesis, we compared the propagation behavior of two different α-synuclein aggregate strains in M83 transgenic mice that either expressed or did not express PrPC.