Ravinandan Venkatasubramanian

3 weeks ago | biorxiv.org | Ravinandan Venkatasubramanian |Mary A. Darrah |Sophia A. Mahoney |David Hutton

AbstractBackground: Mechanisms underlying Doxorubicin (Doxo) chemotherapy-induced aortic stiffening are incompletely understood. Objectives: Determine the role of cellular senescence and the senescence-associated secretory phenotype (SASP) in mediating Doxo-induced aortic stiffening and the influence of senolytic therapy.