Rebeca Lapresa

May 23, 2024 | nature.com | Daniel Jimenez-Blasco |Jesús Agulla |Rebeca Lapresa |Marina Garcia-Macia |Darío García-Rodríguez |Yannick Jeanson | +4 more

AbstractThe energy cost of neuronal activity is mainly sustained by glucose1,2. However, in an apparent paradox, neurons modestly metabolize glucose through glycolysis3,4,5,6, a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase–fructose-2,6-bisphosphatase-3 (PFKFB3)3,7,8, a key glycolysis-promoting enzyme.

Sep 3, 2023 | biorxiv.org | Daniel Jimenez-Blasco |Jesús Agulla |Rebeca Lapresa |Marina Garcia-Macia

Abstractapparent paradox, neurons only weakly metabolize glucose through glycolysis, a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (Pfkfb3), a key glycolysis-promoting enzyme. To evaluate the in vivo physiological significance of this hypo-glycolytic metabolism, here we genetically engineered mice with their neurons transformed into active glycolytic cells through Pfkfb3 expression.