Rebekah Penrice-Randal

Jun 14, 2024 | biorxiv.org | Rebekah Penrice-Randal |Eleanor G Bentley |Parul Sharma |Adam Kirby

AbstractObjectives: Immunocompromised individuals are susceptible to severe COVID-19 and potentially contribute to the emergence of variants with altered pathogenicity due to persistent infection. This study investigated the impact of immunosuppression on SARS-CoV-2 infection in k18-hACE2 mice and the effectiveness of antiviral treatments in this context during the first 7 days of infection. Methods Mice were immunosuppressed using cyclophosphamide and infected with a B lineage of SARS-CoV-2.

May 28, 2024 | mdpi.com | Jordan Clark |Rebekah Penrice-Randal |Parul Sharma |Xiaofeng Dong

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

Feb 28, 2024 | biorxiv.org | Rebekah Penrice-Randal |Eleanor G Bentley |Parul Sharma |Adam Kirby

AbstractObjectives: Immunocompromised individuals are susceptible to severe COVID-19 and potentially contribute to the emergence of variants with altered pathogenicity due to persistent infection. This study investigated the impact of immunosuppression on SARS-CoV-2 infection in k18-hACE2 mice and the effectiveness of antiviral treatments in this context. Methods: Mice were immunosuppressed using cyclophosphamide and infected with a B lineage of SARS-CoV-2.