Reinhard Buettner

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Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score - npj Precision Oncology

Nov 10, 2024 | nature.com | Robert A. Wild |Reinhard Buettner |Matthias Scheffler

AbstractOur recently published K1N2-score robustly predicts KEAP1/NFE2L2-mutations and pathway activation status, while its accessibility might be limited. We tested if the RNA expression data of six pathway-related genes and NQO1-IHC might be a reliable alternative using 348 KEAP1/NFE2L2 mutation-enriched NSCLC.

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