Reneau Castore

2 months ago | biorxiv.org | Magdalena Circu |Reneau Castore |Brian Latimer |Stephanie R. Shames

AbstractLegionella pneumophila is an environmental Gram-negative bacterium that parasitizes unicellular protozoa and can cause severe pulmonary infections when aerosolized bacteria are inhaled by humans. One critical aspect of Legionella pathogenesis is the establishment in the cytosol of infected macrophages of a unique ER-derived vacuole, that requires a sustained supply of host lipids during expansion.