Rex L. Chisholm

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Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network

Apr 29, 2024 | cell.com | Anna Lewis |Rex L. Chisholm |John Connolly |Edward D. Esplin

Decision 5: Communicate the differential performance between validation groups? The next decision was whether to inform patient participants and their healthcare providers about the differential performance of the PRSs revealed by validation. The ELSI group provided input that each of two strategies considered were ethically defensible.

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