Robert Cross

Mar 14, 2024 | science.org | Ian A. Hatton |Tiffany C. Vance |Sarah Moraïs |Robert Cross

Research ArticleANTIVIRALSRobert W. Cross https://orcid.org/0000-0001-7718-1522, Courtney Woolsey https://orcid.org/0000-0003-3389-0137, [...] , Victor C. Chu https://orcid.org/0000-0002-1879-5281 [email protected], Darius Babusis https://orcid.org/0000-0001-5599-1671, [...] , Roy Bannister https://orcid.org/0000-0002-6311-1440, Meghan S. Vermillion https://orcid.org/0000-0002-1602-7027, Romas Geleziunas, Kimberly T.

Sep 16, 2023 | nature.com | Robert Cross

AbstractTaxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro reconstitution, we demonstrate that single-isotype α1β4 GDP-tubulin lattices are stabilised and expanded by 10 µM taxol, as reported by accelerated microtubule gliding in kinesin motility assays, whereas single-isotype α1β3 GDP-tubulin lattices are stabilised but not expanded.

Aug 23, 2023 | academic.oup.com | Robert Cross

Marburg virus (MARV) has caused numerous sporadic outbreaks of severe hemorrhagic fever in humans. Human case fatality rates of Marburg Virus Disease (MVD) outbreaks range from 20-90%. Viral genotypes of MARV can differ by over 20%, suggesting variable virulence between lineages may accompany this genetic divergence.