Robert J. Allaway

1 month ago | biorxiv.org | Hua Li |Alexander Pemov |Robert J. Allaway |David Muir

AbstractNeurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant in the NF1 gene. The most characteristic feature of the condition NF1 is the neurofibroma, a benign, multi-cellular tumor which initiates when a cell of the Schwann cell lineage gains a somatic pathogenic variant of the other NF1 allele.