Robert Owens

Jun 11, 2024 | nature.com | Aaron Boussina |Supreeth P. Shashikumar |Robert Owens |Christopher A. Longhurst |Shamim Nemati

Correction to: npj Digital Medicine https://doi.org/10.1038/s41746-023-00986-6, published online 23 January 2024Table 3 and the citation in the text were missing in this article. The original article has been corrected.

Feb 26, 2024 | nature.com | Giorgio Quer |Robert Owens |Jill Waalen |Matteo Gadaleta |Jennifer M. Radin |Jay Pandit | +2 more

Prior studies have shown that sleep duration peri-vaccination influences an individual’s antibody response. However, whether peri-vaccination sleep affects real-world vaccine effectiveness is unknown. Here, we tested whether objectively measured sleep around COVID-19 vaccination affected breakthrough infection rates. DETECT is a study of digitally recruited participants who report COVID-19-related information, including vaccination and illness data. Objective sleep data are also recorded through activity trackers. We compared the impact of sleep duration, sleep efficiency, and frequency of awakenings on reported breakthrough infection after the 2nd vaccination and 1st COVID-19 booster. Logistic regression models were created to examine if sleep metrics predicted COVID-19 breakthrough infection independent of age and gender. Self-reported breakthrough COVID-19 infection following 2nd COVID-19 vaccination and 1st booster. 256 out of 5265 individuals reported a breakthrough infection after the 2nd vaccine, and 581 out of 2583 individuals reported a breakthrough after the 1st booster. There was no difference in sleep duration between those with and without breakthrough infection. Increased awakening frequency was associated with breakthrough infection after the 1st booster with 3.01 ± 0.65 awakenings/hour in the breakthrough group compared to 2.82 ± 0.65 awakenings/hour in those without breakthrough (P < 0.001). Cox proportional hazards modeling showed that age < 60 years (hazard ratio 2.15, P < 0.001) and frequency of awakenings (hazard ratio 1.17, P = 0.019) were associated with breakthrough infection after the 1st booster. Sleep duration was not associated with breakthrough infection after COVID vaccination. While increased awakening frequency during sleep was associated with breakthrough infection beyond traditional risk factors, the clinical implications of this finding are unclear.

Jan 22, 2024 | nature.com | Aaron Boussina |Supreeth P. Shashikumar |Robert Owens |Christopher A. Longhurst |Shamim Nemati

AbstractSepsis remains a major cause of mortality and morbidity worldwide. Algorithms that assist with the early recognition of sepsis may improve outcomes, but relatively few studies have examined their impact on real-world patient outcomes. Our objective was to assess the impact of a deep-learning model (COMPOSER) for the early prediction of sepsis on patient outcomes.