Robert Suchting

Sep 18, 2024 | digitalcommons.library.tmc.edu | Heather Webber |Jin Yoon |Constanza de Dios |Robert Suchting

The behavioral economic measure drug demand and the neural measure late positive potential (LPP) are two measures of motivational value that have been associated with drug relapse risk and treatment outcomes. Despite having overlapping themes, no studies have directly compared drug demand and LPP.

Jul 29, 2024 | digitalcommons.library.tmc.edu | Robert Suchting |Charles Green |Constanza de Dios |Jessica Vincent

BACKGROUND: Medication development research for cocaine use disorder (CUD) has been a longstanding goal in addiction research, but has not resulted in an FDA-approved treatment. Rising cocaine use rates underscore the need for efficient adaptive designs. This study compared differences between two doses of the selective serotonin reuptake inhibitor (SSRI) citalopram (versus placebo) on duration of cocaine abstinence and applied adaptive decision rules to select the 'best efficacy' dose.