Rohit V. Pappu

Dec 12, 2023 | biorxiv.org | Tingting Wu |Matthew King |Mina S. Farag |Rohit V. Pappu

AbstractRecent computations suggest that biomolecular condensates that form via macromolecular phase separation are network fluids featuring spatially inhomogeneous organization of the underlying molecules. Computations also point to unique conformations of molecules at condensate interfaces. Here, we test these predictions using high-resolution structural characterizations of condensates formed by intrinsically disordered prion-like low complexity domains (PLCDs).