Rohit V. Pappu

4 weeks ago | cell.com | Tapojyoti Das |Fatima Zaidi |Mina S. Farag |Kiersten M. Ruff |Tharun Selvam Mahendran |Anurag Singh | +6 more

Keywordsphase separationfibril formationsupersaturationamyotrophic lateral sclerosisfrontotemporal dementiastress granuleRNP granuleprion-like domainmetastabilitysink potentialIntroductionCytoplasmic stress granules (SGs) are inhomogeneous biomolecular condensates that form via condensation in response to polysomal runoff, caused by cellular stresses.

Dec 12, 2023 | biorxiv.org | Tingting Wu |Matthew King |Mina S. Farag |Rohit V. Pappu

AbstractRecent computations suggest that biomolecular condensates that form via macromolecular phase separation are network fluids featuring spatially inhomogeneous organization of the underlying molecules. Computations also point to unique conformations of molecules at condensate interfaces. Here, we test these predictions using high-resolution structural characterizations of condensates formed by intrinsically disordered prion-like low complexity domains (PLCDs).