Rohtash Kumar

Jul 23, 2024 | pubs.rsc.org | Suraj Kumar Singh |Rohtash Kumar |Navneet Dubey |Chandrakumar Appayee

Synthesis and application of chiral cis-2,5-disubstituted pyrrolidine organocatalysts The first synthesis of chiral cis-2,5-disubstituted pyrrolidine organocatalysts is described. Their application for the enantioselective Michael addition of nitromethane to α,β-unsaturated aldehydes with excellent yield (up to 91%) and enantioselectivity (up to >99% ee) is demonstrated. Another catalytic application for the reaction of 2,4-hexadienal with nitrostyrene is also showcased.