Ronald C. Wek

Nov 12, 2024 | jbc.org | Michael Holmes |Ronald C. Wek |William Sullivan

Keywordstranslationgene expressionstress responseparasiteToxoplasmaIntroductionCellular adaptation and differentiation processes in response to cellular stresses are initiated by a reprogramming of gene expression. A central feature of this reprograming is rapid lowering of global protein synthesis in favor of selective translation of a subset of mRNAs that include transcription factors that activate genes for stress remediation or differentiation (1-3).