Rong Liu

2 months ago | frontiersin.org | Rong Liu |Xiang Xi |Hui Zhuo |Yiwei Gu |Xiao Ma

2 months ago | nature.com | Rong Liu

AbstractAging is a major risk factor for Alzheimer’s disease (AD). With the prevalence of AD increased, a mechanistic linkage between aging and the pathogenesis of AD needs to be further addressed. Here, we report that a small ubiquitin-related modifier (SUMO) modification of p53 is implicated in the process which remarkably increased in AD patient’s brain.

Jan 10, 2025 | mdpi.com | Kai Liu |Tao REN |Rong Liu |Zhangli Lan

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Dec 5, 2024 | mdpi.com | Jianhua Zhang |Rong Liu |Haoran Wang |Yi He

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Dec 2, 2024 | nature.com | Rong Liu |Wei Zhang

AbstractProinsulin translation and folding is crucial for glucose homeostasis. However, islet β-cell control of Proinsulin translation remains incompletely understood. Here, we identify OSGEP, an enzyme responsible for t6A37 modification of tRNANNU that tunes glucose metabolism in β-cells. Global Osgep deletion causes glucose intolerance, while β-cell-specific deletion induces hyperglycemia and glucose intolerance due to impaired insulin activity.