Rongting Huang

May 14, 2024 | biorxiv.org | Rongting Huang |Xianjie Huang |Yin Tong |Helen Yan

AbstractSomatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical sparsity of such data makes it challenging to identify allele-specific CNAs, particularly in complex clonal structures.