Rooshanie Nadia Ejaz

Nov 13, 2023 | biorxiv.org | Mar Ruiz |Eva Maria Steiner-Rebrova |Rooshanie Nadia Ejaz |Claudia Sybille Kielkopf

AbstractTargeted delivery of therapeutics to specific cells is a major bottleneck towards personalized medicine. The extracellular injection system (eCIS) of Serratia entomophila, the antifeeding prophage (Afp), promises potential for drug delivery purposes. However, the precise mechanism of action, toxin location, and Afp loading remain unclear. Here, we reveal a minimal N-terminal signal peptide (NtSP) of the toxin Afp18, that plays a key role in toxin packing.