Rowan Durrant

Nov 25, 2024 | journals.plos.org | Rowan Durrant |Christina A Cobbold |Kirstyn Brunker |Kathryn Campbell |PLOS Pathogens

Citation: Durrant R, Cobbold CA, Brunker K, Campbell K, Dushoff J, Ferguson EA, et al. (2024) Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus. PLoS Pathog 20(11): e1012740. https://doi.org/10.1371/journal.ppat.1012740Editor: Thomas Hoenen, Friedrich-Loeffler-Institut, GERMANYReceived: October 27, 2023; Accepted: November 10, 2024; Published: November 25, 2024Copyright: © 2024 Durrant et al.

Sep 4, 2023 | biorxiv.org | Christina A Cobbold |Kirstyn Brunker |Kathryn Campbell |Rowan Durrant

AbstractThe molecular clock is a method for measuring the rate of virus evolution but the key assumption that mutations accumulate on the genome at a constant rate over time does not always hold true. While modelling approaches exist to accommodate deviations from a strict molecular clock, assumptions about rate variation may not fully represent the underlying evolutionary processes and can affect the accuracy of clock calibration and divergence time estimates.