Roxanne Chiu

Nov 21, 2024 | biorxiv.org | Tuhin Guha |Edward D. Esplin |Aaron M Horning |Roxanne Chiu

AbstractColorectal cancer (CRC) is the third leading cause of cancer mortality in the United States. Familial adenomatous polyposis (FAP) is a hereditary syndrome that raises the risk of developing CRC, with total colectomy as the only effective prevention. Even though FAP is rare (0.5% of all CRC cases), this disease model is well suited for studying the early stages of malignant transformation as patients form many polyps reflective of pre-cancer states.