Ruchun Dai
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frontiersin.org
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Jun 5, 2023 |
frontiersin.org | Bone Diseases |Qi Lu |Yan Jiang |Ruchun Dai
1 IntroductionPrimary hypertrophic osteoarthropathy (PHO) is an inherited disorder of skeletal and skin abnormalities. The history of the disease dates back to 1868, when Friedreich first described “hyperostosis of the entire skeleton” in two brothers (1).
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