
Rui Li
Articles
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Feb 18, 2025 |
nature.com | Feng Gu |Tonimarie Catalan |Alexandria Miller |Domingo E. Uceda |Rui Li |Emily M Wittrup | +12 more
Heart failure (HF) is a highly heterogeneous condition, and current methods struggle to synthesize extensive clinical data for personalized care. Using data from 343 HF patients, we developed mechanistic computational models of the cardiovascular system to create digital twins. These twins, consisting of optimized measurable and unmeasurable parameters alongside simulations of cardiovascular function, provided comprehensive representations of individual disease states. Unsupervised machine learning applied to digital twin-derived features identified interpretable phenogroups and mechanistic drivers of cardiovascular death risk. Incorporating these features into prognostic AI models improved performance, transferability, and interpretability compared to models using only clinical variables. This framework demonstrates potential to enhance prognosis and guide therapy, paving the way for more precise, individualized HF management.
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Jan 31, 2025 |
mdpi.com | Ziqi Chen |Ji Wang |Rui Li |Yujun Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jan 28, 2025 |
pubs.acs.org | Haotian Wang |Chuanqi Cheng |Rui Li |Cuibo Liu
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Jan 28, 2025 |
dx.doi.org | Haotian Wang |Chuanqi Cheng |Rui Li |Cuibo Liu
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Jan 9, 2025 |
dovepress.com | Yingjian Tan |Yue Kang |Rui Li
Dear editor We read with great interest the article by Liu et al titled “Parabolic Changes in Pain Scores Among Partial Herpes Zoster Patients: A Retrospective Study”.1 The study provides valuable insights into the unique parabolic pain trajectory observed in a subset of herpes zoster (HZ) patients and its correlation with post-herpetic neuralgia (PHN).
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