Rui Zhi Dong

Jun 16, 2024 | nature.com | Rui Zhi Dong

AbstractVariants in voltage-gated sodium channel (VGSC) genes are implicated in seizures, epilepsy, and neurodevelopmental disorders, constituting a significant aspect of hereditary epilepsy in the Chinese population. Through retrospective analysis utilizing next-generation sequencing (NGS), we examined the genotypes and phenotypes of VGSC-related epilepsy cases from a cohort of 691 epilepsy subjects.

May 17, 2024 | mdpi.com | Baofeng Zhang |Rui Zhi Dong |Wei Li |Yue Zhao

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Mar 7, 2024 | nature.com | Yifei Lu |Yong Chen |Rui Zhi Dong

AbstractUndifferentiated pleomorphic sarcoma (UPS) is a highly aggressive malignant soft tissue tumor with a poor prognosis; however, the identity and heterogeneity of tumor populations remain elusive. Here, eight major cell clusters were identified through the RNA sequencing of 79,569 individual cells of UPS. UPS originates from mesenchymal stem cells (MSCs) and features undifferentiated subclusters.

Jan 31, 2024 | pubs.rsc.org | Rui Zhi Dong |Ru bo Zhang |Jiangsu College |Chao Shen

Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study† Aim: This study used urinary caffeine and its metabolites to evaluate their relationships with liver steatosis and advanced liver fibrosis. Methods: A total of 2068 adult participants with required data were filtered from the 2009–2014 National Health and Nutrition Examination Survey (NHANES) cycles.

Jan 15, 2024 | pubs.rsc.org | Rui Zhi Dong |Ru bo Zhang |Chao Shen |Ya Shen

Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study Aims: This study used urinary caffeine and its metabolites to evaluate its relationship with liver fibrosis and steatosis. Methods: A total of 2069 adult participants with needed data were filtrated from the 2009-2014 National Health and Nutrition Examination Survey (NHANES) cycles.