Ruiwu Liu

Jul 2, 2024 | biorxiv.org | Michelle Hu |Ruiwu Liu |Noemi Fernández Castro |Liliana Sanchez

AbstractDerivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have the capacity to target tumor cell populations resistant to currently employed therapeutic agents. However, a major barrier to clinical translation of the amilorides is their modest cytotoxic potency, with estimated IC50 values in the high micromolar range.