Ruoxi Pi

Nov 1, 2023 | nature.com | Zhijian Li |Laura Amaya |Ruoxi Pi |Sean Wang |Alok Ranjan |Robert M. Waymouth | +2 more

AbstractThe introduction of more effective and selective mRNA delivery systems is required for the advancement of many emerging biomedical technologies including the development of prophylactic and therapeutic vaccines, immunotherapies for cancer and strategies for genome editing. While polymers and oligomers have served as promising mRNA delivery systems, their efficacy in hard-to-transfect cells such as primary T lymphocytes is often limited as is their cell and organ tropism.