Ruth O’Regan

Jun 23, 2023 | acsjournals.onlinelibrary.wiley.com | Arya Roy |Vasanthan Muthusamy Kumarasamy |Ajay Dhakal |Ruth O’Regan

Sacituzumab govitecan SG is an ADC comprising humanized immunoglobulin G1 targeting the trophoblast cell surface antigen (Trop2), which is overexpressed in most human solid epithelial cancers, conjugated with the active metabolite of irinotecan (SN-38) by a hydrolysable C2LA covalent linker.31, 32 The conjugate has intermediate serum stability and is cleaved in low pH within the tumor microenvironment and the lysosomes, possessing a DAR of 7.6:1.31 It was initially approved for use in...