Ruud J.B

Aug 13, 2024 | particleandfibretoxicology.biomedcentral.com | A. F |Kongens Lyngby |Ruud J.B

Prior to exposing rats in the main biodistribution study, two pilot studies were performed with CeO2 NM-212 and TiO2 NM-105 ENMs. To set the exposure concentration in the pilot study, multiple-path particle dosimetry (MPPD V3.14) modelling was used to estimate the deposited fractions in the different lung regions (for details see additional file 1). The mass median aerodynamic diameter (MMAD) was assumed around 1.4 μm for both ENMs based on earlier reported values [11, 12, 18, 19].