Ryan Frank

Jun 20, 2024 | alz-journals.onlinelibrary.wiley.com | Michelle M. Mielke |Ryan Frank |Luke R. Christenson |Robert Reid

1 BACKGROUND Premenopausal bilateral oophorectomy (PBO) causes abrupt endocrine dysfunction (e.g., loss of estrogen, progesterone, testosterone, and an increase in gonadotropins). Studies suggest that females with PBO are at an increased risk of cognitive impairment and dementia,1-9 but few neuroimaging studies have been conducted to clarify the underlying pathogenesis.