Ryan Lu

Sep 22, 2024 | biorxiv.org | Ryan Lu |Jithu Krishna |Yasin Alp |S Thayumanavan

AbstractExtracellular targeted protein degradation (eTPD) is an emerging modality to regulate protein levels without genomic interruption. Current strategies co-opt lysosome-targeting receptors (LTRs) that are ubiquitously present in most cells, offering a high success rate of eTPD across cell types and tissues. Opening up the binding complementarity requirement from LTRs to any overexpressed cell surface receptor offers to endow eTPD platforms with new cellular targeting capabilities.