Ryan Tuck

Nov 26, 2024 | nature.com | Xiaoying Shen |Ryan Tuck |Robert Edwards |Yunfei Wang |Kshitij Wagh |Kevin Saunders | +3 more

AbstractThe details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore the pediatric immune environment in neonatal macaque undergoing Simian-HIV infection. Simian-HIV infection of 11 pairs of therapy-naive dams and infant rhesus macaques for 24 months results in heterologous HIV-1 neutralizing antibodies in 64% of young macaques compared to 18% of adult macaques.