Ryner Lai

1 week ago | rarediseaseadvisor.com | Ryner Lai

Physical activity before or during pregnancy was not associated with negative maternal/neonatal outcomes; however, physical activity was not statistically significantly associated with positive outcomes either. These findings, published in Frontiers in Medicine, report that maternal/neonatal health is of particular importance among already vulnerable patient populations, such as those with hemolytic disease of the fetus and newborn (HDFN).

1 week ago | rarediseaseadvisor.com | Ryner Lai

A patient with KIT-C-negative systemic mastocytosis (SM) initially presented with severe anemia alongside intraosseous-intramuscular hemorrhage in a case report recently published in Cureus. Atypical presentations in SM can result in diagnostic delays, complicating management. This case study demonstrates the importance of maintaining a high index of clinical suspicion in patients who present with unexplained cytopenia and bleeding.

1 week ago | hematologyadvisor.com | Ryner Lai

Idiopathic multicentric Castleman disease (iMCD) is associated with a significant economic burden in the United States, highlighting the need for early diagnosis and the implementation of timely interventions to drive down costs, according to a poster presented at the EHA 2025 Congress. Studies indicate a clear morbidity risk associated with iMCD. Because of the diagnostic challenges associated with the disease, the true incidence and treatment burden of iMCD has been a challenge to characterize.

1 week ago | rarediseaseadvisor.com | Ryner Lai

Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated disease that is often characterized by myelitis attacks. It is generally accepted that early detection and diagnosis is key, and that the early initiation of medical intervention can improve long-term outcomes. The relationship between the time to treatment and prognosis is highlighted in a study published in Brain and Behavior by Zhou and colleagues.

1 week ago | renalandurologynews.com | Ryner Lai

The presence of renal hyperfiltration (RHF), whether it persists or disappears over time, is associated with increased risks of cardiovascular events and all-cause mortality, according to a poster presentation at the 62nd European Renal Association (ERA) Congress in Vienna, Austria. RHF that develops, then disappears is also linked with progression to kidney failure. Previous cross-sectional studies have linked RHF to poor clinical outcomes.