Saba Heydari-Seradj

Nov 19, 2024 | biorxiv.org | Yu Wang |Yunxiao Zhang |Verina H. Leung |Saba Heydari-Seradj

AbstractCompared to the well-established functions of sympathetic innervation, the role of sensory afferents in adipose tissues remains less understood. Recent work revealed the anatomical and physiological significance of adipose sensory innervation; however, its molecular underpinning remains unclear. Here, using organ-targeted single-cell RNA sequencing, we identified the mechanoreceptor PIEZO2 as one of the most prevalent receptors in fat-innervating dorsal root ganglia (DRG) neurons.