Sabita Roy

Feb 1, 2025 | biorxiv.org | Mark Oppenheimer |Junyi Tao |Sabita Roy |Shamsudheen Moidunny

AbstractThe development of anxiety during protracted opioid withdrawal heightens the risk of relapse into the cycle of addiction. Understanding the mechanisms driving anxiety during opioid withdrawal could facilitate the development of therapeutics to prevent negative affect and promote continued abstinence. Our lab has previously established the gut microbiome as a driver of various side effects of opioid use, including analgesic tolerance and somatic withdrawal symptoms.