Sai-Nan Zhou

Dec 4, 2024 | pubs.rsc.org | Jun-Long Zhan |Sai-Nan Zhou |Yu Wang |Rui Liu

Direct β-C–H ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions A TEMPO-mediated β-ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions is herein described. This reaction provides a straightforward and highly efficient route to β-keto alkyl substituted enaminoesters for the first time, which could be rapidly and efficiently converted into synthetically useful 2-alkoxycarbonyl functionalized 1,5-diketones.