Salma A.S. Abosabie

Sep 16, 2024 | biorxiv.org | Moua Yang |Alexandra Boye-Doe |Alexandra Barr |Salma A.S. Abosabie

AbstractRas-like (Ral) GTPases play essential regulatory roles in many cellular processes, including exocytosis. Cycling between GDP- and GTP-bound states, Ral GTPases function as molecular switches and regulate effectors, specifically the multi-subunit tethering complex exocyst. Here, we show that Ral isoform RalB controls regulated exocytosis of Weibel-Palade bodies (WPBs), the specialized endothelial secretory granules that store hemostatic protein von Willebrand factor.