Sandrine Huot

1 month ago | biorxiv.org | Sandrine Huot |PAUL FORTIN |Cynthia Laflamme |Philippe Tessier

AbstractPurpose: Systemic lupus erythematosus is an autoimmune disease hallmarked by a plethora of autoantibodies, interferon-signature, auto-immune complexes, dysregulation of soluble factors in circulation, and abnormal neutrophils. We hypothesized that lupus humoral "environment" could be responsible, at least in part, for these neutrophil abnormalities. We characterized the neutrophil phenotype in a cohort of lupus patients and assessed the impact of the "lupus environment".